Protein and Glycan Mimicry in HIV Vaccine Design
نویسندگان
چکیده
منابع مشابه
CD4 binding determinant mimicry for HIV vaccine design
The immunodominant epitopes expressed by the HIV-1 envelope protein gp120 are hypermutable, defeating attempts to develop an effective HIV vaccine. Targeting the structurally conserved gp120 determinant that binds host CD4 receptors (CD4BD) and initiates infection is a more promising route to vaccination, but this has proved difficult because of the conformational flexibility of gp120 and immun...
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Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making them promising leads for vaccine design. Wild-type Env glycoproteins lack detectable affinity for supersite-bnAb germline precursors and are therefore unsuitable immunogens to prime supersite-bnAb responses. We employed mammalian cell sur...
متن کاملHIV and Molecular Mimicry
For more than three decades, molecular mimicry has been considered a contributing factor in viral pathogenesis. The phenomenon comes about when viral antigens share epitopes with host cell proteins. Because tolerance is thought never to be complete, the mimicking microbe can induce anti-self antibodies, a state of autoimmunity, with resulting immunopathogenesis. This mode of attack seems preemi...
متن کاملAnti-Carbohydrate HIV Vaccine Design
R. Pantophlet (ed.), HIV Glycans in Infection and Immunity, DOI 10.1007/978-1-4614-8872-9_6, © Springer Science+Business Media New York 2014 Abstract HIV has evolved a number of strong defense mechanisms, including extensive glycosylation of its surface envelope glycoprotein, to evade host immune responses. Nevertheless, the discovery of a series of glycan-dependent broadly neutralizing antibod...
متن کاملDesign and tests of an HIV vaccine.
It is likely that a successful vaccine against HIV will need to stimulate the innate immune system, generate high levels of neutralising antibody, strong cellular immune responses, and mucosal immunity. Early efforts to develop HIV vaccines attempted to use the virus glycoprotein, gp120, to induce neutralising antibody, but did not take into account the trimeric structure of the native glycopro...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2019
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2019.04.016